Evaluation of the effect of enzymatic hydrolyzate of the bursa of broiler chickens on cytotoxic activity and nonspecific immunity

The use of biologically active substances tissue origin for the creation additives and immunomodulatory drugs is an important area scientific research in field nutrition pharmacology. aim work to evaluate effect enzymatic hydrolysate from fabricium bag broiler chickens on cytotoxicity nonspecific immunity mice against background experimental salmonella infection using biotechnological methods. For experiment, three equal groups white mongrel were formed. All laboratory animals fed daily seven days with at a dose 750 mg/kg (therapeutic dose), 150 (0.2 therapeutic dose) 3,750 (five doses). At same time, control group received intragastric water volume. 24 hours after last intake hydrolysate, intraperitoneally infected culture Salmonella enteritidis 92. study reveals absence cytotoxic properties impaired cell viability cultures L929, J774.1A, HeLa S3, K562, HST116 exposure various concentrations 0.02 10 mg/ml. It should be noted that there pronounced MCF-7 tumor cells concentration 5 mg/ml, which suggests possibility prevention diseases. As result it has been proved administration increased LD50 index survival rate causative agent salmonellosis by 1.5 times. Based conducted studies, shown lymphoid does not violate mammalian exhibit metabolism healthy cells, indicates its safety. In experiment mice, activation revealed.